TABLE 1 Global Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 2 Global Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 3 Global Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 4 North America Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 5 North America Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 6 North America Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 7 U.S. Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 8 U.S. Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 9 U.S. Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 10 Canada Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 11 Canada Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 12 Canada Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 13 Rest of North America Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 14 Rest of North America Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 15 Rest of North America Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 16 UK and European Union Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 17 UK and European Union Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 18 UK and European Union Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 19 UK Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 20 UK Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 21 UK Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 22 Germany Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 23 Germany Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 24 Germany Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 25 Spain Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 26 Spain Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 27 Spain Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 28 Italy Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 29 Italy Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 30 Italy Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 31 France Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 32 France Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 33 France Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 34 Rest of Europe Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 35 Rest of Europe Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 36 Rest of Europe Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 37 Asia Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 38 Asia Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 39 Asia Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 40 China Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 41 China Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 42 China Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 43 Japan Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 44 Japan Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 45 Japan Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 46 India Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 47 India Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 48 India Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 49 Australia Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 50 Australia Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 51 Australia Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 52 South Korea Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 53 South Korea Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 54 South Korea Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 55 Latin America Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 56 Latin America Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 57 Latin America Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 58 Brazil Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 59 Brazil Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 60 Brazil Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 61 Mexico Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 62 Mexico Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 63 Mexico Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 64 Rest of Latin America Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 65 Rest of Latin America Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 66 Rest of Latin America Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 67 Middle East and Africa Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 68 Middle East and Africa Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 69 Middle East and Africa Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 70 GCC Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 71 GCC Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 72 GCC Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 73 South Africa Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 74 South Africa Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 75 South Africa Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 76 North Africa Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 77 North Africa Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 78 North Africa Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 79 Turkey Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 80 Turkey Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 81 Turkey Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
TABLE 82 Rest of Middle East and Africa Non-insulin Therapies for Diabetes Market By Drug Class, 2022-2032, USD (Million)
TABLE 83 Rest of Middle East and Africa Non-insulin Therapies for Diabetes Market By Route of Administration, 2022-2032, USD (Million)
TABLE 84 Rest of Middle East and Africa Non-insulin Therapies for Diabetes Market By End-user, 2022-2032, USD (Million)
Market Overview
The non-insulin therapies for diabetes market encompasses a range of pharmaceuticals and treatments used to manage diabetes mellitus without the use of insulin. This includes oral medications such as sulfonylureas, biguanides (e.g., metformin), thiazolidinediones, and DPP-4 inhibitors, as well as newer classes of drugs like SGLT2 inhibitors and GLP-1 receptor agonists. These therapies are primarily used to improve blood glucose control in patients with type 2 diabetes and are often prescribed in conjunction with lifestyle modifications such as diet and exercise. Non-insulin diabetes therapies are critical for managing type 2 diabetes, which affects millions of people worldwide. The increasing prevalence of diabetes, driven by rising obesity rates, aging populations, and lifestyle factors, is a major factor driving demand for these treatments. Non-insulin medications are favored for their ease of use, particularly in the early stages of type 2 diabetes, and for their ability to reduce blood glucose levels without the risk of causing hypoglycemia that is sometimes associated with insulin use. Furthermore, many of these medications also offer cardiovascular and weight loss benefits, which are important given the high risk of heart disease in diabetic patients. Projected to grow at a Compound Annual Growth Rate (CAGR) of 5.9%, the non-insulin therapies for diabetes market is set to expand significantly. This growth is facilitated by continuous advancements in pharmacological research, leading to the development of more effective and safer medications with fewer side effects. Additionally, the increasing global incidence of diabetes and greater awareness of the disease are prompting more people to seek treatment, further stimulating market growth. Emerging markets, in particular, present a substantial growth opportunity as healthcare systems improve and access to medications increases. As patient and practitioner preferences evolve towards less invasive treatment options that offer improved glycemic control and other health benefits, the demand for non-insulin diabetes therapies is expected to rise robustly.
Global Increase in Type 2 Diabetes Prevalence
A significant driver of the non-insulin therapies for diabetes market is the global increase in the prevalence of type 2 diabetes, primarily fueled by rising obesity rates, aging populations, and sedentary lifestyles. With obesity being a major risk factor for type 2 diabetes, countries experiencing higher rates of obesity—especially in urban settings where lifestyle factors contribute to poor health outcomes—are seeing a corresponding rise in diabetes cases. This trend necessitates effective management strategies for diabetes, driving demand for non-insulin therapies that are easier to administer and manage compared to insulin. These therapies are integral to controlling blood sugar levels and reducing the risk of diabetes-related complications, thus increasing their uptake among the growing diabetic population.
Emergence of Advanced Drug Classe
An emerging opportunity within the non-insulin therapies for diabetes market is the development of advanced drug classes, such as GLP-1 receptor agonists and SGLT2 inhibitors. These therapies not only aid in blood glucose management but also offer additional benefits like weight loss and cardiovascular health, addressing two major concerns in diabetic care. The effectiveness of these drugs in managing blood sugar levels along with their additional health benefits positions them as attractive options for healthcare providers and patients seeking comprehensive diabetes management solutions. This trend is likely to continue as ongoing research and development in pharmacology yield more sophisticated treatments that cater to the multifaceted needs of diabetic patients.
Cost of Advanced Diabetes Therapies
One major restraint in the market is the high cost associated with advanced diabetes therapies. While new drug classes offer significant benefits, they also come with higher price tags, which can be prohibitive for many patients, particularly in low- and middle-income countries. The affordability and accessibility of these drugs remain major concerns, as health insurance coverage and healthcare disparities affect the ability of patients to access these newer, more effective treatments. This economic barrier restricts the widespread adoption of the latest therapies, limiting market growth in regions where diabetes prevalence is high but healthcare spending is low.
Regulatory and Market Access Challenges
A significant challenge in the non-insulin therapies for diabetes market is navigating the complex regulatory environment and achieving market access. New diabetes therapies must undergo rigorous testing and approval processes which can be lengthy and costly. Additionally, gaining formulary inclusion and ensuring reimbursement across different health systems can be a formidable task due to the stringent cost-benefit analyses performed by healthcare payers. Manufacturers must demonstrate not only the efficacy and safety of their products but also provide compelling evidence of cost-effectiveness compared to existing therapies. This requirement often necessitates extensive clinical trials and robust health economic studies, adding to the complexity and cost of bringing new therapies to market.
Market Segmentation by Drug Class
In the non-insulin therapies for diabetes market, the segment of DPP-4 Inhibitors currently generates the highest revenue. These inhibitors are favored for their efficacy in managing blood glucose levels with minimal risk of causing hypoglycemia and no weight gain, making them a popular choice among healthcare providers for a wide range of diabetic patients. Meanwhile, the Sodium-glucose co-transporter-2 (SGLT2) Inhibitors are projected to exhibit the highest Compound Annual Growth Rate (CAGR). The growing preference for SGLT2 inhibitors is due to their dual benefits of reducing blood glucose and associated cardiovascular risks, which is crucial for diabetic patients who are typically at higher risk of cardiovascular diseases. These inhibitors have also been gaining traction due to their additional benefits like weight loss and blood pressure reduction, aligning well with the comprehensive management of diabetes and related metabolic conditions.
Market Segmentation by Route of Administration
Regarding the route of administration in the non-insulin therapies for diabetes market, Oral medications dominate in terms of revenue due to their ease of use, patient compliance, and widespread availability. Most non-insulin diabetes therapies are administered orally, which is highly preferred by patients over injections due to its non-invasiveness and convenience. However, the Intramuscular route, particularly for newer drug classes like GLP-1 analogs, is expected to experience the highest CAGR. This trend is driven by the efficacy of GLP-1 analogs in not only managing blood sugar levels but also promoting significant weight loss and providing cardiovascular benefits. Although intramuscular administration is less convenient than oral tablets, the compelling therapeutic benefits of GLP-1 analogs are making them increasingly popular, especially among patients with advanced diabetes symptoms or those who have not achieved optimal glucose control with oral drugs alone.
Geographic Segment
In 2023, North America held the highest revenue percentage in the non-insulin therapies for diabetes market, largely due to the high prevalence of diabetes, well-established healthcare infrastructure, and significant healthcare spending in the region. The United States, in particular, is a major contributor, driven by advanced treatment options, robust R&D activities, and a strong presence of leading pharmaceutical companies. Additionally, the increasing incidence of obesity, a key risk factor for diabetes, further propels the demand for effective diabetes management solutions. Looking forward, the Asia-Pacific region is expected to experience the highest Compound Annual Growth Rate (CAGR) from 2024 to 2032. This growth will be driven by the rapid urbanization, rising prevalence of type 2 diabetes, improving healthcare infrastructure, and growing awareness about diabetes management. Countries like China and India, with their large populations and increasing diabetic patient base, are anticipated to significantly contribute to this growth. Furthermore, government initiatives to improve healthcare access and affordability are likely to enhance the adoption of non-insulin therapies in this region.
Competitive Trends
In 2023, the competitive landscape of the non-insulin therapies for diabetes market was marked by strategic initiatives from top players such as GSK plc, Eli Lilly and Company, Sumitomo Pharma, Intarcia Therapeutics, Servier Laboratories, Pfizer Inc., Merck & Co., Inc., Dong-A Pharmaceutical Co., Ltd., Luye Pharma Group, and Eurofarma Laboratories SA. These companies focused on expanding their product portfolios, enhancing their market presence, and investing in R&D to develop innovative therapies. For instance, Eli Lilly and Company and Merck & Co., Inc. emphasized the development of advanced GLP-1 receptor agonists and SGLT2 inhibitors, which have shown promising results in managing blood glucose levels and providing additional health benefits. Over the forecast period from 2024 to 2032, these players are expected to continue focusing on strategic collaborations and partnerships to strengthen their market positions and leverage complementary strengths in drug development and distribution. Moreover, entering emerging markets with high growth potential, particularly in the Asia-Pacific region, will likely be a key strategy to capture new patient segments and expand their global footprint. Investment in digital health technologies and patient-centric solutions to improve diabetes management and adherence to medication is also anticipated to be a significant trend, aligning with the broader move towards personalized medicine and integrated care approaches.
